Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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Alfacalcidol(41294-56-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Alfacalcidol
Synonyms
1a-Hydroxyvitamin D3
1-Hydroxycholecalciferol
9,10-Secocholesta-5,7,10(19)-triene-1,3-diol, (1a,3b,5Z,7E)-
CAS
41294-56-8
Formula
C27H44O2
Molecular Weight
400.65
EINECS
255-297-1
RTECS
VS2851000
RTECS Class
Drug; Reproductive Effector
Merck
12,4864
Beilstein/Gmelin
1916848
Beilstein Reference
5-06

Physical and Chemical Properties

Appearance
Fine white crystals
Solubility in water
Insoluble
Melting Point
132 - 133
Vapor Pressure
2E-13 (25 C)
pKa/pKb
13.82 (pKa)
Heat Of Vaporization
92.83 kJ/mol
Usage
A form of vitamin d. It is converted rapidly in the liver to the active metabolite, 1,25-dihydroxycholecalciferol (calcitriol).

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage
Keep tightly closed. Store at -20 C

Hazards Identification

Inhalation
May be fatal if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Skin
May cause skin irritation. May be fatal if absorbed through skin.
Eyes
May cause eye irritation.
Ingestion
May be fatal if swallowed.
Hazards
Emits toxic fumes under fire conditions.
EC Risk Phrase
26/27/28
EC Safety Phrase
28 36/37 45
UN (DOT)
2811

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves.
Respirators
Government approved respirator.
Exposure Effects
Very toxic by inhalation, in contact with skin and if swallowed.

Fire Fighting Measures

Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire Potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
2811
Hazard Class
6.1
Packing Group
I
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