Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Ziconotide acetate(107452-89-1)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Ziconotide acetate
Synonyms
omega-Conopeptide MVIIA (Conus)
omega-Conotoxin M VIIA
CAS
107452-89-1
Formula
C102H172N36O32S7
Molecular Weight
2639.13
Merck
12,10471

Physical and Chemical Properties

Appearance
White to off-white powder. Odorless.
Solubility in water
Slihtly soluble
Usage
Ligand for binding studies of voltage sensitive calcium channels.

First Aid Measures

Ingestion
If swallowed, give large quantities of water to drink and get medical attention immediately. Never give anything by mouth to an unconscious person.
Inhalation
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin
Wash exposed area with soap and water. Get medical advice if irritation develops.
Eyes
Wash thoroughly with running water. Get medical advice if irritation develops.

Handling and Storage

Storage
Store at or below -20C (Deep Freeze) in a desiccated environment and protected from light. Always take precautions to avoid creating airborne dust or mists. Powdered material should be handled under hooded ventilation.

Hazards Identification

Inhalation
Inhalation of dust may produce an allergic reaction. The risk of allergic sensitization increases with repeated direct exposure.
Skin
No information found, but skin contact may produce an allergic reaction. The risk of allergic sensitization increases with repeated direct exposure. Ziconotide has potent pharmacological activity and is classified as an OEB-3* material.
Ingestion
Ingestion may produce an allergic reaction. May cause central nervous system effects similar to those from therapeutic doses.

Exposure Controls/Personal Protection

Personal Protection
Wear appropriate gloves; lab coat, nylon coveralls or disposable Tyvek suit; safety glasses, safety shoes, and disposable booties. Safety glasses. Maintain eye wash fountain and quick-drench facilities in work area.
Respirators
An air-purifying respirator (P95 or other type providing a higher level of protection) should be worn by all personnel in the immediate area in cases where non-ventilated containment is used, where significant amounts of material (e.g., more than 2 grams) are used, or where the material may become airborne (as through grinding, etc.). If using a ventilated enclosure that has not been validated, wear a half-mask respirator equipped with HEPA cartridges until the enclosure is validated for use.
Exposure Effects
Repeated contact can cause sensitization and potentially significant reactions to very small exposures. Persons with prior hypersensitivity to ziconotide should avoid exposures. May have additive central nervous system effects with alcohol or other CNS depressants consumed before or after exposure.

Fire Fighting Measures

Fire Fighting
Use any means suitable for extinguishing surrounding fire. In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Follow handling guidance appropriate for OEB-3 potent compounds.
Fire Potential
Not considered to be a fire hazard.

Accidental Release Measures

Small spills/leaks
Pick up and place in a suitable container for reclamation or disposal, using a method that does not generate dust.

Stability and Reactivity

Stability
Stable under ordinary conditions of use and storage.
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