(1R,2S)-(-)-Ephedrine(299-42-3)

Product Name
(1R,2S)-(-)-Ephedrine

Synonyms
(1R,2S)-2-Methylamino-1-phenylpropan-1-ol
Biophedrin
Eciphin
Efedrin
Ephedral
Sanedrine

CAS
299-42-3

Formula
C10H15NO

Molecular Weight
165.26

EINECS
206-080-5

RTECS
KB0700000

RTECS Class
Drug; Reproductive Effector; Human Data; Natural Product

Beilstein/Gmelin
972533

EC Index Number
614-023-00-4

EC Class
Harmful

Appearance
Waxy white to off-white solid, crystals or granules.

Solubility in water
50 g/L

Melting Point
217 - 218

Boiling Point
132 (3 torr)

Density
1.124 g/cm3 (20 C)

Usage
Optically pure amines used as resolving agents include alkaloids such as ephedrine. Medication.

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture. Store protected from light.

Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.

Inhalation
May cause respiratory tract irritation.

Skin
May cause skin irritation.

Eyes
May cause eye irritation.

Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects
Elevated blood pressure may occur, accompanied by rapid heart rate may occur. Low heart rate has been reported following overdoses of phenylpropanolamine and as a late presentation following norepinephrine depletion. Increased temperature may occur. anxiety, nervousness, insomnia, muscle tremor, seizures, altered mental status and cerebral hemorrhage and ischemia may be noted. Toxic psychosis may develop following acute overdoses or abuse of sympathomimetics.

Flash Point
85

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Incompatibilities
Moisture, oxidizing agents.

Stability
Stable under normal temperatures and pressures.

Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.