Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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氨苄青霉素(69-53-4)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Ampicillin
Synonyms
(2S,5R,6R)-6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
1,9-Nonanediamine
Alpen
Amfipen
Aminobenzylpenicillin
D(-)-alpha-Aminobenzylpenicillin
D-(-)-alpha-Aminopenicillin
Nonane-1,9-diamine
CAS
646-24-2
CAS
69-53-4
Formula
C16H19N3O4S
Formula
C9H22N2
Molecular Weight
158.29
Molecular Weight
349.41
EINECS
200-709-7
EINECS
211-470-3
RTECS
XH8350000
RTECS Class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,628
Beilstein/Gmelin
1737533
Beilstein/Gmelin
629178
Beilstein Reference
4-04-00-01364
EC Class
irritant

Physical and Chemical Properties

Appearance
White solid.
Appearance
White, crystalline powder. Odorless or has a faint odor characteristic of the penicillins.
Solubility in water
1 gm dissolves in about 90 ml
Solubility in water
575 g/L (20 C)
Melting Point
35 - 38
Melting Point
202
Boiling Point
258
Vapor Pressure
0.014 (25 C)
pKa/pKb
3.03 (pKb)
pKa/pKb
2.61 (pKa)
Heat Of Vaporization
49.6 kJ/mol
Usage
Antibiotic.

First Aid Measures

Ingestion
Get medical aid. Wash mouth out with water.
Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Inhalation
Causes respiratory tract irritation.
Skin
Causes skin irritation.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
Eyes
Causes eye irritation.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Storage
Store in a cool, dry place. Store in a tightly closed container.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.

Hazards Identification

Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Skin
Contact dermatitis may occur due to hypersensitivity reactions.
Ingestion
Diarrhea, nausea, vomiting, and abdominal pain may occur.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
EC Risk Phrase
R 34
EC Safety Phrase
S 26 36/37/39 45
UN (DOT)
3265

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
drowsiness, myoclonus, seizures, and coma may occur following large iv doses. Neurological side effects may be more common in patients with impaired renal function.

Fire Fighting Measures

Flash Point
110
Autoignition
285
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire Potential
Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Disposal Code
3
Incompatibilities
Acids, acid chlorides, acid anhydrides, oxidizing agents.
Stability
No data.
Stability
Stable under normal temperatures and pressures. Absorbs carbon dioxide from the air.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
3265
Hazard Class
8
Packing Group
I; II; III
HS Code
2921 29 00
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