Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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(+)-Griseofulvin(126-07-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
(+)-Griseofulvin
Synonyms
7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
Amudane
Fulvistatin
Polygris
Sporostatin
Xuanjing
CAS
126-07-8
Formula
C17H17ClO6
Molecular Weight
352.77
EINECS
204-767-4
RTECS
WG9800000
RTECS Class
Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product
Merck
12,4571
Beilstein/Gmelin
95226
Beilstein Reference
5-18-05-00150

Physical and Chemical Properties

Appearance
White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless.
Solubility in water
Insoluble
Melting Point
218 - 222
Boiling Point
570
Vapor Pressure
5E-13 (25 C)
Density
1.4 g/cm3
Partition Coefficient
2.36
Heat Of Vaporization
85.6 kJ/mol
Usage
Medication, fungicide.

First Aid Measures

Ingestion
Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation
Remove from exposure to fresh air immediately.
Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.

Handling and Storage

Storage
Store in a cool, dry place. Keep container closed when not in use. Hormones and antibiotics room.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Inhalation
Symptoms of exposure to this compound may include urticaria, headaches, confusion, dizziness, nausea, diarrhea, photosensitivity and leukopenia. Other symptoms may include epigastric distress, fever and arthralgia. It may cause renal damage and porphyria. It may also cause peripheral neuritis, syncope and blurred vision. Exposure has caused skin rashes, fatigue, proteinuria and, rarely, angioneurotic edema, paresthesia and lupus erythematosus. Symptoms may include dryness of the mouth, an altered sensation of taste, gastrointestinal disturbances, severe allergic reactions, erythema multiforme, exfoliative dermatitis, candidiasis, depression, irritability and, rarely, hepatitis.
Skin
See inhalation.
Eyes
See inhalation
Ingestion
See inhalation.

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Exposure Effects
headache, dizziness, disorientation, lethargy, fatigue, and mental confusion may be noted. Paresthesia secondary to peripheral neuropathy has been reported following therapeutic use. Use in pregnancy is contraindicated. Griseofulvin is classified as FDA pregnancy category C. There is no data concerning breast milk.
Exposure limit(s)
OSHA: Possible Select carcinogen

Fire Fighting Measures

Flash Point
228
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Fire Potential
This material is probably combustible.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.

Stability and Reactivity

Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
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