Supplier Product Identification Physical and Chemical Properties First Aid Measures Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information
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Acemetacin(53164-05-9)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information

Product Identification

Product Name
Acemetacin
Synonyms
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester
1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]acetic acid
CAS
53164-05-9
Formula
C21H18ClNO6
Molecular Weight
415.83
EINECS
258-403-4
RTECS
NL3521400
RTECS Class
Drug; Reproductive Effector
Merck
12,27
Beilstein/Gmelin
501672
Beilstein Reference
5-22-05-00241

Physical and Chemical Properties

Solubility in water
Slightly soluble
Boiling Point
637
Vapor Pressure
4E-17 (25 C)
pKa/pKb
2.60 (pKa)
Heat Of Vaporization
98.9 kJ/mol
Usage
An nsaid that specifically potentiates the cytoxicity of anthracyclines.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Hazards Identification

Inhalation
TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.
Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
Eyes
See Inhalation.
Ingestion
See Inhalation.
Hazards
Emits toxic fumes under fire conditions.
EC Risk Phrase
26/27/28
EC Safety Phrase
22 25 36/37/39 45
UN (DOT)
2811

Exposure Controls/Personal Protection

Personal Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Exposure Effects
Very toxic by inhalation, in contact with skin and if swallowed.

Fire Fighting Measures

Flash Point
339
Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire Potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.
Combustion Products
Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number
2811
Hazard Class
6.1
Packing Group
II
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