Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Andrographolide(5508-58-7)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Andrographolide
Synonyms
(3E,4S)-3-[2-[(1S,4aS,5R,6R,8aR)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decalin-1-yl]ethylidene]-4-hydroxy-oxolan-2-one
3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene- 1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5- alpha,6-alpha,8a-alpha))-2(3H)-furanone
Andrographis
CAS
5508-58-7
Formula
C20H30O5
Molecular Weight
350.46
EINECS
226-852-5
RTECS
LU3490750
RTECS Class
Drug; Natural Product
Merck
13,638
Beilstein/Gmelin
42762
Beilstein Reference
4-18-00-02357

Physical and Chemical Properties

Solubility in water
Insoluble
Melting Point
231 - 232
Boiling Point
557
Vapor Pressure
1E-14 (25 C)
Density
1.21 g/cm3
pKa/pKb
12.32 (pKa)
Heat Of Vaporization
96.4 kJ/mol
Usage
May boost immune response.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Handling and Storage

Storage
Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation
Material may be irritating to mucous membranes and upper respiratory tract.
Skin
May cause skin irritation.
Eyes
May cause eye irritation.
Hazards
Emits toxic fumes under fire conditions.
EC Safety Phrase
22 24/25

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Exposure Effects
The chemical, physical, and toxicological properties of this product have not been thoroughly investigated. Exercise due care.

Fire Fighting Measures

Flash Point
196
Fire Fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.
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