Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole > 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole(22232-71-9)

5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole(22232-71-9)

Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole
Synonyms
5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazol
5-(4-Chlorophenyl)-2,5-dihydro-3H-Imidazo
5-p-Chlorophenyl-2,3-dihydro-5H-Imidazo(2,1-A)isoindol-5-ol
An 448
Dimagrir
Magrilon
CAS
22232-71-9
Formula
C16H13ClN2O
Molecular Weight
284.74
EINECS
244-857-0
RTECS
NI2975000
RTECS Class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,5801
Beilstein/Gmelin
546547
Beilstein Reference
5-24-04-00402

Physical and Chemical Properties

Appearance
Crystals from acetone-hexane. Faint odor to odorless.
Solubility in water
insoluble
Melting Point
215 - 217
Usage
Medication.

First Aid Measures

Ingestion
Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Tablets should be stored in tight containers at a temperature less than 25C.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation
Tachypnea is common. Pulmonary hypertension has been associated with chronic use or abuse which may result from contaminants. Pulmonary edema and ards are unusual complications of severe exposure.
Skin
The skin is usually flushed and diaphoretic.
Ingestion
Vomiting, diarrhea, cramps, anorexia and gastrointestinal hemorrhage may occur.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
Severe elevated body temperature may develop. Elevated blood pressure and rapid heart rate are common. Agitation, confusion, paranoia, delirium, hallucinations, restlessness, hyperactivity, talkativeness, irritability, insomnia, and headache are common. Chorea, dystonia, fasciculations, muscle rigidity, tics, and tremors may develop. Seizures and coma may occur with severe intoxication. Other neurological effects have included stroke and cerebral vasculitis. Serotonin syndrome has occurred.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability
Stable in light, air and heat.
Incompatibilities
Strong oxidizing agents.