Home > 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine > 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine(50-48-6)
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine(50-48-6)
Supplier Product Identification
Physical and Chemical Properties
First Aid Measures
Handling and Storage
Hazards Identification
Exposure Controls/Personal Protection
Fire Fighting Measures
Accidental Release Measures
Stability and Reactivity
Product Identification
Product Name
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
Synonyms
5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
Adepress
Adepril
Amitryptyline
Damilen
Damitriptyline
5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene
Adepress
Adepril
Amitryptyline
Damilen
Damitriptyline
CAS
50-48-6
50-48-6
Formula
C20H23N
C20H23N
Molecular Weight
277.41000000000003
277.41000000000003
EINECS
200-041-6
200-041-6
RTECS
HO9275000
HO9275000
RTECS Class
Drug; Reproductive Effector; Human Data
Drug; Reproductive Effector; Human Data
Merck
12,511
12,511
Beilstein/Gmelin
2217885
2217885
Physical and Chemical Properties
Solubility in water
9.71 mg/L @ 24 C
9.71 mg/L @ 24 C
Melting Point
196-197
196-197
pKa/pKb
9.4 (pKa)
9.4 (pKa)
Partition Coefficient
4.6
4.6
Usage
Medication.
Medication.
First Aid Measures
Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
Handling and Storage
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Hazards Identification
Inhalation
Respiratory depression is common with significant overdoses and may develop rapidly. Atelectasis, aspiration pneumonitis, pneumonia and ARDS may develop in patients with severe overdose.
Respiratory depression is common with significant overdoses and may develop rapidly. Atelectasis, aspiration pneumonitis, pneumonia and ARDS may develop in patients with severe overdose.
Eyes
Mydriasis, blurred vision and dry mouth are common anticholinergic effects. Nystagmus may occur.
Mydriasis, blurred vision and dry mouth are common anticholinergic effects. Nystagmus may occur.
Ingestion
Bowel ischemia, pseudo-obstruction and esophageal spasm have been associated with overdose. Decreased GI motility and delayed gastric emptying are common anticholinergic effects. Pancreatitis is a rare effect of overdose.
Bowel ischemia, pseudo-obstruction and esophageal spasm have been associated with overdose. Decreased GI motility and delayed gastric emptying are common anticholinergic effects. Pancreatitis is a rare effect of overdose.
Exposure Controls/Personal Protection
Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
Respiratory depression may occur rapidly after overdose. Both elevated body temperature and reduced body temperature have been reported. Abnormally low blood pressure occurs with severe overdose. Rapid heart rate is a common anticholinergic effect. CNS depression, lethargy, disorientation, and ataxia are common.
Respiratory depression may occur rapidly after overdose. Both elevated body temperature and reduced body temperature have been reported. Abnormally low blood pressure occurs with severe overdose. Rapid heart rate is a common anticholinergic effect. CNS depression, lethargy, disorientation, and ataxia are common.
Fire Fighting Measures
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Accidental Release Measures
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability and Reactivity
Stability
No data.
No data.
Incompatibilities
Strong oxidizing agents.
Strong oxidizing agents.
Contact
More
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Fax:86-10-82849933
- WebSite:http://www.jkchemical.com
- Company Name:LGM Pharma
- Tel:1-(800)-881-8210
- Fax:615-250-9817
- WebSite:http://www.lgmpharma.com
- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
- Tel:021-54306202 13764082696
- Fax:
- WebSite:https://www.hanhongsci.com
- Company Name:Syntechem Co.,Ltd
- Tel:
- Fax:E-Mail Inquiry
- WebSite:http://www.syntechem.com/
- Company Name:Beijing HuaMeiHuLiBiological Chemical
- Tel:010-56205725
- Fax:010-65763397
- WebSite:http://www.huabeibiochem.com/