Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
Home > Oxymetazoline > Oxymetazoline(1491-59-4)

Oxymetazoline(1491-59-4)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Oxymetazoline
Synonyms
2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline
Afrin
Hazol
Oxylazine
Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-
Rhinofrenol
CAS
1491-59-4
Formula
C16H24N2O
Molecular Weight
260.38
EINECS
216-079-1
RTECS
SK1050000
RTECS Class
Drug; Reproductive Effector
Merck
12,7100
Beilstein/Gmelin
886303
Beilstein Reference
5-23-11-00424

Physical and Chemical Properties

Appearance
Crystals from benzene.
Solubility in water
Slightly soluble
Melting Point
181-183
pKa/pKb
3.47 (pKb)
Usage
Medication.

First Aid Measures

Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation
Decreased respirations and intermittent apnea may be noted.
Ingestion
Nausea and vomiting may be noted.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Exposure Effects
Elevated blood pressure is common initially; abnormally low blood pressure may occur; low heart rate is common in children; reduced body temperature and respiratory depression have been reported. headache, nervousness, tremors, and insomnia are frequently reported. Marked drowsiness and mild coma with alternating periods of hyperactivity and thrashing behavior have been reported in children.

Fire Fighting Measures

Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability
Stable in light and heat, and is nonhygroscopic hydrochloride.
Incompatibilities
Strong oxidizing agents.
Contact More