Supplier Product Identification Physical and Chemical Properties First Aid Measures Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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21-Desoxybetamethasone(382-67-2)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
21-Desoxybetamethasone
Synonyms
9-Fluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione
CAS
382-67-2
Formula
C22H29FO4
Molecular Weight
376.47
EINECS
206-845-3
RTECS
TU3834000
RTECS Class
Reproductive Effector; Hormone
Merck
12,2975
Beilstein/Gmelin
2228097
Beilstein Reference
6-08

Physical and Chemical Properties

Solubility in water
Insoluble
Melting Point
217
Vapor Pressure
2E-13 (25 C)
pKa/pKb
12.80 (pKa)
Heat Of Vaporization
92.9 kJ/mol
Usage
A topical steroid used to treat inflammation caused by a number of conditions such as allergic reactions, eczema, and psoriasis.

First Aid Measures

Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Hazards Identification

Inhalation
Material is irritating to mucous membranes and upper respiratory tract.
EC Risk Phrase
20/21/22 36/37/38 40 43
EC Safety Phrase
22 26 36

Exposure Controls/Personal Protection

Personal Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Exposure Effects
Harmful. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. May cause sensitization by skin contact. Target organ(s): Pituitary. Poss

Fire Fighting Measures

Flash Point
276
Fire Fighting
Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.
Decomposition
Carbon monoxide, Carbon dioxide, Hydrogen fluoride.
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