| Name | ZM241385 |
| Description | ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor. |
| Cell Research | Nitric oxide (NO) production is assessed by measuring the amount of nitrite, a stable metabolic product of NO that provides an indirect measurement of NO, by using the Griess diazotization reaction. Briefly, 24 h after incubation with 1.0 µM CG21680 or 1.0 µM ZM241385 or exposure to SMF, samples of medium (150 µl) are collected from cells and mixed with 130 µl dWater and with 20 µl Griess reagent using instruction supplied by the manufacturer. After a 30 min incubation period at room temperature, the samples are evaluated spectrophotometrically at 548 nm and OD values-in comparison with a standard curve is determined in culture medium by using serial dilutions of sodium nitrite-represented total stable metabolites of NO. (Only for Reference) |
| In vitro | ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7?min) OGD period, and protect CA1 neuron and astrocyte from injury[4]. |
| In vivo | ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 1.7 mg/mL (5 mM)
DMSO : 55 mg/mL (163.04 mM)
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| Keywords | P1 receptor | Inhibitor | inhibit | ZM 241385 | ZM-241385 | Adenosine Receptor | ZM241385 |
| Inhibitors Related | Theophylline monohydrate | Diphylline | Acefylline | Nitrobenzylthioinosine | Aminophylline | Inosine | Theobromine | Istradefylline | Theophylline | Adenosine antagonist-1 | Doxofylline | FK-453 |
| Related Compound Libraries | 神经退行性疾病化合物库 | 经典已知活性库 | 抗阿尔茨海默症化合物库 | 膜蛋白靶向化合物库 | 抗帕金森病化合物库 | 抑制剂库 | NO PAINS 化合物库 | 肿瘤免疫治疗小分子化合物库 | 已知活性化合物库 | GPCR靶点分子库 |
United States
