| Name | ZINC69391 |
| Description | ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis. |
| In vitro | In U-87 MG and LN229 cells, ZINC69391 (0-125 μM) reduces cell proliferation of human glioma cells. ZINC69391 (50-100 μM) triggers cell cycle arrest[1]. ZINC69391 inhibits the growth of U937, HL-60, KG1A, and Jurkat cells (IC50s = 41-54 μM). In HL-60, U937, and KG1A cell lines, ZINC69391 (50 μM) triggers an increase in apoptotic cells. In LN229 cells, ZINC69391 (50 and 100 μM) augments the enzymatic activity of caspase 3 and increases the percentage of cells in the sub-G0/G1 phase in a concentration-dependent manner[3]. |
| In vivo | In specific pathogen-free female BALB/c inbred mice (bearing F3II cells), ZINC69391 (25 mg/kg; i.p) impairs metastatic lung colonization and reduces by about 60% the formation of total metastatic lung colonies[2]. |
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 20 mg/mL (64.66 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | ZINC69391 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | PPI Inhibitor Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library |
United States
