| Name | Zinc pyrithione |
| Description | Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump. |
| In vitro | In exposed mussel tissues, Zinc pyrithione accumulates rapidly, with the rate of accumulation being proportional to both exposure concentration and time. Despite a 7-day LC50 (lethal concentration for 50% of the population) of 8.27 μM in relatively higher concentrations of Zinc pyrithione, this indicates a potential threat to coastal ecosystems and marine life, necessitating further investigation into its sub-lethal biological effects. |
| In vivo | As a specific synthetic potentiator, Zinc pyrithione activates homotypic and heterotypic M channels by inducing a resting potential. It is considered a zinc complex. The Pyrithione ligand (formally a monoanion) chelates with Zn2+ through oxygen and iron-sulfur centers. In the crystalline state, Zinc pyrithione exists as a centrosymmetric dimer, with each zinc atom coordinated to two sulfur and three oxygen centers. However, in solution, the dimers dissociate through the cleavage of zinc-oxygen bonds. Although Zinc pyrithione is a dimer, its activity causing cytoplasmic membrane depolarization may originate from the monomer, with an effective concentration for half-maximum effect (K1/2) of approximately 0.3 mM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 20 mg/mL (62.95 mM), Sonication is recommended.
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| Keywords | Bacterial | inhibit | Inhibitor | Proton Pump | OM1563 | Fungal | OM 1563 | Zinc pyrithione |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Potassium gluconate | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Geraniol | Dimethyl sulfoxide | Crystal Violet |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Fungal Compound Library | FDA-Approved Drug Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
