Ziconotide acetate

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Product details:

1.What is Ziconotide acetate?

ziconotide (trade name Prialt) is a compound of 25 amino acids and three disulfide peptides derived from the South Pacific Marine snail Conusmagus. It is the first novel neurotherapeutic drug, N-type calcium channel blocker (NCCB). It can selectively act on N-type electrosensitive calcium channels in dendrites and axons, thereby inhibiting the initial injurious stimulus. It is suitable for patients with severe chronic pain who require intrathecal therapy and are intolerant or ineffective to other analgesic treatments (such as the application of systemic analgesics or intrathecal morph ine injection, etc.). Intrathecal injection of Ziconotide can treat postherpetic neuralgia, phantom limb pain, HIV-associated neuropathic pain, refractory cancer pain, and post-operative pain.

2.What is it used for?

Ziconotide, the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.

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