| Name | zerumbone |
| Description | Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects. |
| Animal Research | Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. |
| In vivo | Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone. LPS-induced expressions of proinflammatory mediators, iNOS and COX-2, were inhibited by zerumbone. In addition, NFκB activation and Akt phosphorylation were inhibited by zerumbone in LPS-induced ALI. Suggested that the protective mechanisms of zerumbone on endotoxin-induced ALI were via inhibition of Akt-NFκB activation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (229.01 mM), Sonication is recommended.
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| Keywords | HSV | Herpes simplex virus | anti-proliferative | sesquiterpene | Epstein-Barr | virus | inhibit | Inhibitor | zerumbone | Monocyclic | anti-cancer | anti-inflammatory | antioxidant |
| Inhibitors Related | Butylated hydroxytoluene | Propyl gallate | L-Tartaric acid | Neohesperidin | Sulbutiamine | Adenosine 5'-monophosphate monohydrate | Oxyresveratrol | m-Coumaric acid | Idoxuridine | L-Cystine | Acyclovir | Trolox |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Anti-Viral Compound Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |
United States
