Name | Zamifenacin fumarate |
Description | Zamifenacin fumarate (UK-76654 fumarate) is a potent, gut-selective antagonist of the muscarinic M3 receptor. |
In vivo | Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg)[2]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : 1 mg/mL (1.88 mM), Sonication and heating to 60℃ are recommended. DMSO : 55 mg/ml (103.46 mM), Sonication is recommended.
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Keywords | gut | UK 76654 | bowel | inhibit | Zamifenacin Fumarate | Inhibitor | Muscarinic acetylcholine receptor | UK-76654 | UK76654 Fumarate | muscarinic | mAChR | motility | UK 76654 Fumarate | syndrome | irritable | Zamifenacin fumarate | Zamifenacin | UK76654 | colonic | UK-76654 Fumarate |
Inhibitors Related | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Adenine | Choline chloride | Propoxur |
Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max |