| Name | Withanolide A |
| Description | Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. |
| In vitro | A quantitative structure activity relationship (QSAR) model was developed by a forward stepwise multiple linear regression method to predict the activity of Withanolide Analogs against human breast cancer. The most effective QSAR model for anticancer activity against the SK-Br-3 cell showed the best correlation with activity (r2=0.93 and rCV2 =0.90). Similarly, cross-validation regression coefficient (rCV2=0.85) of the best QSAR model against the MCF7/BUS cells showed a high correlation (r2=0.91). In particular, compounds CID 73621, CID 435144, CID 301751 and CID 3372729 have a marked antiproliferative activity against the MCF7/BUS cells, while 2,3-dihydrowithaferin A-3-beta-O-sulfate, withanolide 5, Withanolide A, withaferin A, CID 10413139, CID 11294368, CID 53477765, CID 135887, CID 301751 and CID 3372729 have a high activity against the Sk-Br-3 cells compared to standard drugs 5-fluorouracil (5-FU) and camptothecin[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (116.87 mM), Sonication is recommended.
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| Keywords | Withanolide A | TNF-α | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | EGFR |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Metronidazole | Fumaric acid | Citric Acid Triammonium | 1,8-Cineole | Tributyrin | L-Methionine | Cystamine dihydrochloride | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Parasitic Compound Library | Rare Natural Product Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
