| Name | Verapamil hydrochloride |
| Description | Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent. |
| Cell Research | Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1]. |
| In vitro | Verapamil exhibits antiarrhythmic properties, reduces myocardial oxygen consumption in rats, and preserves Cx43 protein. |
| In vivo | Verapamil and Diltiazem essentially inhibit the hydrolase activity of recombinant CES2, with inhibition constants (Ki) of 0.25 ± 0.02 μM and 3.84 ± 0.99 μM, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (101.82 mM)
H2O : 24.6 mg/mL (50 mM)
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| Keywords | Ca channels | Verapamil hydrochloride | Verapamil | inhibit | Inhibitor | Verapamil Hydrochloride | pressure | Pgp | ABCB1 | Verapamil hydrochlorid | P-gp | Ca2+ channels | P-glycoprotein | lysosomotropic | Calcium Channel | MDR1 | high | (±)-Verapamil | angina | Palbociclib | Cytochrome P450 | Calcan Hydrochloride | CD243 | Cluster of differentiation 243 | CYP3A4 | Multidrug resistance protein 1 | antiarrhythmic | CYPs | blood |
| Inhibitors Related | L-Ascorbic acid | Naringin |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library |
United States
