| 名称 | Vancomycin hydrochloride |
| 描述 | Vancomycin hydrochloride (Vancomycin HCl) is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. |
| 体外活性 | Vancomycin, a substantial glycopeptide antibiotic with a molecular weight of 1450 Da[1], stands out due to its unique structure and mode of action, distinguishing it from all currently available antibiotics. Its distinctive mechanism targets and inhibits the second stage of cell wall synthesis in susceptible bacteria. Active against an extensive array of Gram-positive species including Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, and enterococci[2], vancomycin is a critical asset in treating various bacterial infections. |
| 体内活性 | Vancomycin is administered via intravenous infusion over a minimum of one hour to reduce the risk of infusion-related adverse effects. In individuals with normal creatinine clearance levels, the distribution phase (α) of vancomycin spans between 30 minutes to 1 hour, while the elimination half-life (β) ranges from 6 to 12 hours. Its distribution volume lies between 0.4–1 L/kg, and its protein-binding capacity varies between 10% and 50%. The efficacy of vancomycin is influenced by factors such as tissue distribution, inoculum size, and protein-binding impacts. Furthermore, vancomycin therapy in infected mice demonstrates significant improvements in clinical outcomes, diarrhea, histopathological scores, and survival rates during the course of treatment. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 33.33 mg/mL (22.43 mM), Sonication is recommended.
DMSO : 55 mg/mL (37.02 mM), Sonication and heating are recommended.
|
| 关键字 | inhibit | Autophagy | Antibiotic | Vancomycin Hydrochloride | Bacterial | Vancomycin | Inhibitor | Vancomycin hydrochloride |
| 相关库 | 环肽库 | 经典已知活性库 | 抗癌临床化合物库 | 天然产物库 | 微生物天然产物库 | FDA 上市药物库 | 抗癌上市药物库 | 高通量筛选天然产物库 | 已知活性化合物库 | 抗癌药物库 |
United States
