Valinomycin (CAS No. 2001-95-8) is a cyclic peptide composed of 12 amino acids, characterized by its lipid-soluble antibiotic properties. It selectively binds to potassium ions (K+) and significantly enhancing their transmembrane diffusion rate by up to 100,000 times. In the biomedical field, valinomycin has diverse applications, including inducing apoptosis, inhibiting oxidative phosphorylation, preventing neuronal differentiation, as well as counteracting endothelin-induced vasoconstriction. Additionally, it can be potentially used as an insecticide or plant growth regulator. In analytical chemistry, valinomycin is utilized to create sensing membranes for potassium-selective electrodes, enabling highly sensitive potassium detection. Its unique molecular structure also makes it an excellent chiral stationary phase for gas chromatography, liquid chromatography, and capillary electrophoresis. Overall, valinomycin's multifunctional properties and broad application prospects make it an ideal choice for research and application across various fields.
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