| Name | Validamycin A |
| Description | Validamycin A is an antibiotic and fungicide that inhibits the alginate enzyme trehalase and thus protects crops from the fungus Rhizoctonia solani, as well as being a reversible inhibitor of tyrosinase. |
| In vitro | Validamycin A (0.1–5 mg/mL, 2-day treatment) significantly inhibited the growth of Xanthomonas oryzae pv. oryzae (Xoo), with a minimum inhibitory concentration of 1 mg/mL. Scanning electron microscopy revealed bubbling and morphological damage on bacterial surfaces, indicating direct antibacterial effects[1]. |
| In vivo | In rice plant models, foliar spraying of Validamycin A (200 μg/mL, once every 3 days for a total of 3 treatments) significantly reduced disease severity caused by Xoo infection, with average lesion length decreased by approximately 60%. The treatment showed effective in vivo disease control without phytotoxicity[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | PBS (pH 7.2) : 10 mg/mL (20.1 mM), Sonication is recommended.
H2O : 120 mg/mL (241.21 mM), Sonication is recommended.
DMSO : 1 mg/mL (2.01 mM), Sonication is recommended.
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| Keywords | Validamycin A |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Ampicillin sodium | Kanamycin sulfate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Doxycycline | Sodium formate | Ethyl linoleate | Ethyl acetoacetate |
| Related Compound Libraries | Food Sourced Compound Library | Bioactive Compound Library | Antioxidant Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
