Name | Valecobulin hydrochloride |
Description | Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516. Valecobulin hydrochloride (CKD-516 hydrochloride) has a potent inhibitory effect on β-tubulin polymerization and has significant anti-tumor activity against solid tumors in mice and humans. |
In vivo | METHODS: Nude mice carrying human colonic HCT116 and human colonic overexpression of the P-gp transporter HCT15 were treated with Valecobulin hydrochloride (CKD-516 hydrochloride) (5 mg/kg and 10 mg/kg, intraperitoneal injection, Q4D 4).
RESULTS The IR of Valecobulin hydrochloride (CKD-516 hydrochloride) in HCT116 nude mice was 36% and 65%, respectively, and tumor growth was significantly inhibited in a dose-dependent manner; Valecobulin hydrochloride (CKD-516 hydrochloride) also showed resistance to MDR The potent antitumor activity of positive cell lines (HCT15), with IRs of 12% and 5%, respectively. [2] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 125 mg/mL (218.13 mM), Sonication is recommended. H2O : 50 mg/mL (87.25 mM), Sonication is recommended.
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Keywords | Valecobulin hydrochloride | antitumor | β-tubulin | Inhibitor | Valecobulin | Microtubule/Tubulin | CKD 516 Hydrochloride | inhibit | prodrug | S516 | CKD516 Hydrochloride | CKD 516 | Valecobulin Hydrochloride | VDA | CKD-516 | CKD-516 Hydrochloride | CKD516 |
Inhibitors Related | Flubendazole | Mebendazole | N-Phenylbenzylamine | T-900607 | 4-Isopropoxybenzoic acid | Oxfendazole | Thiabendazole | Methylene Blue | Methylene Blue trihydrate | Paclitaxel | Benproperine phosphate | 4'-Demethylepipodophyllotoxin |
Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Microtubule-Targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |