| Name | Ursolic acid |
| Description | Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities. |
| In vitro | METHODS: Embryonal carcinoma cells NTERA-2 and NCCIT were treated with Ursolic acid (1-50 µM) for 24 h. Cell viability was measured by MTT assay.
RESULTS: Concentration-dependent inhibition of NTERA-2 and NCCIT cell viability by Ursolic acid treatment. [1]
METHODS: Lung cancer cells H460 and H1975 were treated with Ursolic acid (5-20 nM) for 48 h. Apoptosis was detected by Flow cytometry.
RESULTS: Ursolic acid significantly increased the percentage of Annexin V (+) apoptotic cells compared to control. [2] |
| In vivo | METHODS: To investigate the antidepressant-like effects, Ursolic acid (0.001-10 mg/kg, distilled water with 10% Tween 80) was orally administered to Swiss mice, and the TST, FST, or open-field test was performed 60 min later.
RESULTS: Ursolic acid shortened the immobilization time in TST and FST.The antidepressant-like effect of Ursolic acid in TST may be mediated by the activation of dopamine D1 and D2 receptors interacting with the dopaminergic system. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
Propylene glycol : 4.76 mg/ml (10.42 mM）, Sonification is recommended.
DMSO : 50 mg/mL (109.48 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Endogenous Metabolite | NSC 4060 | Ursolic acid | inhibit | NSC4060 | NSC-167406 | Inhibitor | NSC167406 | Autophagy |
| Inhibitors Related | Sucrose | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Ferulic Acid | Paeonol | Glycerol | Thymidine | Naringin |
| Related Compound Libraries | Drug Repurposing Compound Library | Tobacco Monomer Library | Antiparasitic Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
United States
