| Name | Ursolic acid |
| Description | Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities. |
| In vitro | METHODS: Embryonal carcinoma cells NTERA-2 and NCCIT were treated with Ursolic acid (1-50 µM) for 24 h. Cell viability was measured by MTT assay.
RESULTS: Concentration-dependent inhibition of NTERA-2 and NCCIT cell viability by Ursolic acid treatment. [1]
METHODS: Lung cancer cells H460 and H1975 were treated with Ursolic acid (5-20 nM) for 48 h. Apoptosis was detected by Flow cytometry.
RESULTS: Ursolic acid significantly increased the percentage of Annexin V (+) apoptotic cells compared to control. [2] |
| In vivo | METHODS: To investigate the antidepressant-like effects, Ursolic acid (0.001-10 mg/kg, distilled water with 10% Tween 80) was orally administered to Swiss mice, and the TST, FST, or open-field test was performed 60 min later.
RESULTS: Ursolic acid shortened the immobilization time in TST and FST.The antidepressant-like effect of Ursolic acid in TST may be mediated by the activation of dopamine D1 and D2 receptors interacting with the dopaminergic system. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
Propylene glycol : 4.76 mg/mL (10.42 mM), Sonication is recommended.
DMSO : 50 mg/mL (109.48 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+90% Corn Oil : 2.5 mg/mL (5.47 mM), Sonication is recommeded.
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| Keywords | Ursolic acid | NSC4060 | NSC-167406 | NSC167406 | NSC 4060 | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Autophagy |
| Inhibitors Related | Sucrose | Stavudine | Cysteamine hydrochloride | Hydroxychloroquine | Daidzein | Ferulic Acid | Paeonol | Glycerol | Thymidine | Naringin | Alginic acid | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Tobacco Monomer Library | Antiparasitic Natural Product Library | Immunology/Inflammation Compound Library | Cosmetic Ingredient Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Food as Medicine Compound Library |
United States
