Upatinib sustained-release tablet is a selective JAK inhibitor developed by AbbVie and approved by the National Drug Administration in February 2022 for refractory, moderate-to-severe atopic dermatitis in adults and adolescents 12 years of age and older who do not respond well to or are not suitable for other systemic therapies, such as hormonal or biologic agents. The launch of Upatinib sustained-release tablets provides more options for the treatment of atopic dermatitis patients. Approved by the State Drug Administration in March 2022 for the treatment of adult patients with moderate to severe active rheumatoid arthritis who have poor response or intolerance to one or more TNF inhibitors and adult patients with active psoriatic arthritis (PsA) who have poor response or intolerance to one or more DMARDs. Upatinib sustained-release tablets became the first targeted therapy approved in China to treat PsA, opening a new era of targeted therapy for PsA in China. On February 20, 2023, Upatinib sustained release tablets were approved by the State Food and Drug Administration for the treatment of adult patients with moderate to severe active ulcerative colitis who have poor response to one or more TNF inhibitors or are intolerant or conjunctive, becoming the four approved indications in China after atopic dermatitis, psoriatic arthritis and rheumatoid arthritis. It is also the first approved indication of the drug in the field of gastroenterology in China.
It works by blocking the activity of Janus kinase in the JAK-STAT signaling pathway, an intracellular pathway that plays a major role in the release of pro-inflammatory cytokines that stimulate inflammation in rheumatoid arthritis, psoriatic arthritis, and atopic dermatitis
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