| Name | TTP-8307 |
| Description | TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections. |
| In vitro | TTP-8307 targeted non-structural protein 3A and inhibited the replication of enterovirus B3 (CVB3 Nancy) with an EC50 of 1.2 μM. In addition, TTP-8307 inhibited the replication of three Sabin poliovirus strains, as well as enteroviruses A16 and A21, with EC50s of 0.85 and 5.34 μM, respectively.Meanwhile, TTP-8307 inhibited the replication of human rhinoviruses (HRVs) 2, 29, 39, 45, 63 and 85 was also inhibitory. Mutations in non-structural protein 3A caused resistance to TTP-8307, a novel enterovirus replication inhibitor.
In addition, TTP-8307 inhibits OSBP-dependent viruses, including encephalomyelitis virus (EMCV) and hepatitis C virus (HCV). [1][2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 3.3 mg/mL (7.56 mM), Sonication is recommeded.
DMSO : 80 mg/mL (183.28 mM), Sonication is recommended.
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| Keywords | TTP-8307 | TTP 8307 | RNASynthesis | RNA Synthesis | HCVProtease | HCV Protease | HCV | DNASynthesis | DNA/RNA SynthesisProtease | DNA Synthesis |
| Inhibitors Related | 5-Fluorouracil | Phenytoin sodium | Adenine hemisulfate | Methyl 2-amino-5-bromobenzoate | Deferiprone | Guanidine hydrochloride | Methotrexate disodium | L-Lysine | Adenine | Ofloxacin | Carbazole | Thymidine |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
United States
