| Name | TRV-120027 acetate (1234510-46-3 free base) |
| Description | TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling. |
| In vitro | TRV120027 TFA (100 nM) induces an [Ca2+]i increase in HEK293 cells co-transfected with AT1R, β-arrestin-1, and TRPC3, which are significantly blocked by Pyr3 pre-incubation in HEK293 cells co-transfected with Flag-AT1R-Cherry, HA-β-arrestin-1, and TRPC3-GFP. TRV120027 TFA (100 nM) significantly increases the AT1R and TRPC3 association with the immunoprecipitated β-arrestin-1 in HEK293 cells co-transfected with Flag-AT1R-cherry, TRPC3-GFP, and HA-β-arrestin-1 [2]. |
| In vivo | TRV120027 TFA (i.v.; 0.3 or 1.5 μg/kg per minute; infusion rate, 0.5 mL/min), when added to furosemide, decreases cardiac preload and afterload, systemic and renal vascular resistance, and left ventricular external work while increasing cardiac output and renal blood flow [1]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | TRV120027 acetate (1234510463 free base) | 1234510-46-3 free base | 1234510-46-3 | TRV 120027 acetate (1234510 46 3 free base) | TRV120027 Acetate | TRV 120027 Acetate | TRV-120027 Acetate |
| Inhibitors Related | Tranilast | Enalapril Maleate | Sacubitril/Valsartan | Irbesartan | Losartan | Captopril |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Peptide Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Anti-Hypertension Compound Library |
United States
