| Name | Trovafloxacin mesylate |
| Description | Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM). |
| In vitro | Trovafloxacin mesylate is an inhibitor of TO-PRO-3 uptake by apoptotic cells and inhibits ATP release from apoptotic cells. Trovafloxacin mesylate does not inhibit caspase 3/7 activation, or caspase-mediated PANX1 cleavage during apoptosis[1]. Trovafloxacin mesylate is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin mesylate at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[2]. Trovafloxacin mesylate prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2 cells. Trovafloxacin mesylate (20 µM; 24 hours) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH). Trovafloxacin mesylate (20 µM; 24 hours) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[3]. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 120 mg/mL (234.16 mM), Sonication and heating to 60℃ are recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (7.81 mM), Sonication is recommended.
H2O : 18 mg/mL (35.12 mM), Sonication is recommended.
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| Keywords | TRPVChannel | TRPV Channel | TRPChannel | TRP Channel | Trovafloxacin mesylate | Trovafloxacin Mesylate | Trovafloxacin | topoisomerase-IV | Topoisomerase | Topo IV | TNF | RNASynthesis | RNA Synthesis | pro-inflammatory | pneumococci | panx1 | PANX1 | Pannexin 1 channel (PANX1) | NF-κB | LPS | Inhibitor | inhibit | hepatotoxicity | gyrase | DNASynthesis | DNA-gyrase | DNA Synthesis | DNA | broad-spectrum | Bacterial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Copper(Ⅱ) Sulfate | Guanidine hydrochloride | Doxycycline | Thymidine | BES |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
