| Name | Tris(2,4-di-tert-butylphenyl)phosphate |
| Description | Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) isolated from Vitex negundoL inhibits secretory phospholipase A2 (sPLA2). Tris(2,4-di-tert-butylphenyl)phosphate has anti-inflammatory activity. |
| In vitro | METHODS: KGN, MA-10 and C18-4 cells were treated with Tris(2,4-di-tert-butylphenyl)phosphate (0.1-100 µM) for 48 h. Cell counts were assayed by Hoechst 33342 stained.
RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate was not cytotoxic to any of the 3 cell lines. [1] |
| In vivo | METHODS: To assay acute anti-inflammatory activity in vivo, Tris(2,4-di-tert-butylphenyl)phosphate (50-70 mg/kg, 0.1% sodium carboxymethyl cellulose in 1M phosphate buffer pH 7.2) was The carrageenan-induced foot-plantar edema model in rats was administered.
RESULTS: Tris(2,4-di-tert-butylphenyl) phosphate at doses of 50 mg/kg and 70 mg/kg exhibited significant anti-inflammatory activity in the carrageenan-induced foot-plantar edema model. tris(2,4-di-tert-butylphenyl) phosphate significantly reduced the volume of raw paw edema. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.
Ethanol : 100 mg/mL (150.85 mM), Sonication is recommended.
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| Keywords | Tris(2,4-di-tert-butylphenyl)phosphate | Tris(2,4ditertbutylphenyl)phosphate | Tris(2,4 di tert butylphenyl)phosphate | sPLA2 | secretory | Phospholipase | molecular | Inhibitor | inhibit | docking | anti-inflammatory |
| Inhibitors Related | Neomycin sulfate | 1-Naphthaleneacetic acid potassium salt | trans-Benzylideneacetone | Benzylideneacetone | (E/Z)-Polydatin | Indomethacin | Fluticasone (propionate) | CCR1/5/8 activator 1 | 1-Naphthaleneacetic acid | Darapladib | Lansoprazole | Amentoflavone |
| Related Compound Libraries | Anti-Obesity Compound Library | Natural Product Library for HTS | Lipid Metabolism Compound Library | Anti-Aging Compound Library |
United States
