| 名称 | Trimethylamine N-oxide |
| 描述 | Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging effects of urea.Trimethylamine N-oxide induces inflammation through activation of ROS/NLRP3 inflammasomes, which can induce fibroblast differentiation and cardiac fibrosis. |
| 体外活性 | In vitro, the treatment of fibroblasts with Trimethylamine N-oxide (TMAO) results in an increase in both the size and migration of fibroblasts compared to untreated fibroblasts. TMAO induces an elevation in TGF-β receptor I expression, leading to the phosphorylation of Smad2 and an up-regulation in the expression of α-SMA and collagen I. Concurrently, the ubiquitination of TGF-βRI is decreased in neonatal mouse fibroblasts following Trimethylamine N-oxide treatment. Additionally, Trimethylamine N-oxide inhibits the expression of smurf2 [3].
Trimethylamine N-oxide is commonly found in the tissues of various marine organisms, where it serves as a protective factor against the adverse effects of temperature, salinity, high urea, and hydrostatic pressure [2]. |
| 体内活性 | Trimethylamine N-oxide can be utilized in animal modeling to establish a model of cardiac fibrosis. |
| 存储条件 | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 40 mg/mL (532.55 mM), Sonication is recommended.
H2O : 10 mg/mL (133.14 mM), Sonication is recommended.
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| 关键字 | Trimethylamine N-oxide | Trimethylamine Noxide | Trimethylamine N oxide |
| 相关产品 | Stavudine | Sodium Thiocyanate | Imeglimin hydrochloride | Acetylcysteine | L-Ascorbic acid | α-Vitamin E | Glucosamine | D-(+)-Glucono-1,5-lactone | Lycopene | Naringenin |
| 相关库 | 经典已知活性库 | 天然产物库 | 微生物天然产物库 | 抗纤维化化合物库 | 高通量筛选天然产物库 | 化妆品成分化合物库 | 抗衰老化合物库 | 已知活性化合物库 | 肠道微生物代谢化合物库 |
United States
