| Name | Triclocarban |
| Description | Triclocarban (Cutisan), an antimicrobial agent, is used in personal cleaning products. |
| In vitro | Triclocarban (300 nM) enhances the cytotoxicity of 300 μM H2O2 in rat thymocytes without independently increasing cell death, facilitating H2O2-induced cell death and hence elevating the dead cell population [1]. It exhibits estrogenic activities by inducing luciferase in an ER reporter assay, promoting MCF-7 cell proliferation, up-regulating pS2, and down-regulating ERα at mRNA and protein levels in MCF-7 cells [2]. |
| In vivo | Triclocarban, when used in soap during showering, is significantly absorbed by humans, with its peak concentration (Cmax) in whole blood ranging between 23 nM and 530 nM[1]. While exposure to triclocarban during pregnancy does not impact the viability of pregnancy, exposure during lactation adversely affects offspring survival[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (142.59 mM)
|
| Keywords | Bacterial | endocrine-disrupting | inhibit | Triclocarban | personal | products | cleaning | Inhibitor | antimicrobial |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Pain-Related Compound Library | Bioactive Compound Library | Antibiotics Library | Drug Repurposing Compound Library | Anti-Bacterial Compound Library | NO PAINS Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
