1. Product information
Names
| Name | TM-38837 |
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| Synonym | More Synonyms |
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TM 38837 Biological Activity
| Description | TM38837 is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. TM38837 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. TM38837 reduces propensity for psychiatric side effects[1][2]. |
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| Related Catalog | Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor |
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| Target | CB1 |
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| In Vivo | TM38837 (10-100 mg/kg; p.o.) induces a significant increase in freezing behavior at 100 mg/kg[1]. Animal Model: 7-8 weeks old male C57BL/6 N mice (B6N)[1] Dosage: 10, 30, or 100 mg/kg Administration: p.o. Result: High dose (100 mg/kg) induced a significant increase in freezing behavior. |
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| References | [1]. Micale V, et al. The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows ReducedFear-Promoting Effects in Mice. Front Pharmacol. 2019 Mar 20;10:207. [2]. Klumpers LE, et al. Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects. Br J Clin Pharmacol. 2013 Dec;76(6):846-57. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C30H25Cl2F3N4OS |
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| Molecular Weight | 617.512 |
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| Exact Mass | 616.107849 |
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| LogP | 8.91 |
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| Index of Refraction | 1.635 |
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2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
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