Pharmaceutical Intermediate CAS137330-13-3 Veterinary Raw Material Pure Tilmicosin Phosphate
Tilmicosin phosphate is the phosphate salt of the semi-synthetic antibiotic derivative of desmycosin (tylosin B), a minor co-metabolite of tylosin, prepared by mixing the active tilmicosin with phosphoric acid to provide improved solubility and enhanced pharmacokinetics.
The antibacterial action of pharmacodynamics is similar to that of tylenol, which is mainly resistant to gram-positive bacteria, and is also effective for a small number of gram-negative bacteria and mycoplasma.The activity of mycobacterium tuberculosis, pasteurella and animal mycoplasma was better than that of tylosin.It is reported that 95% of the hemolytic pasteurella strain is sensitive to this product.Internal or subcutaneous injection of the product after absorption fast, the tissue penetration is strong, the distribution volume is large.
| Test Items | Specification: | Results |
| Appearance | Light yellow powder | Light yellow powder |
| Identification | IR spectra is consistent with CRS.
The retention time of the major peak
in the chromatogram of the assay
preparation corresponds to that in
the chromatogram of the standard
preparation,as obtained in the assay. | Conforms |
| pH | 5.0~8.0 | 6.8 |
| Water | ≤5.0% | 3.5% |
| Cis-isomer | 82.0%~88.0% | 84.5% |
| Tran-isomer | 12.0%~18.0% | 15.5% |
Assay
(on dried basis) | ≥75.0% (tilmicosin) | 98% |
China
