Quality Pharmaceutical Intermediate Tianeptine Sodium CAS 30123-17-2 for Nootropic
Basic Info
Product Name:Tianeptine sodium salt
Synonyms:
TIANEPTINE SODIUM;TIANEPTINE SODIUM SALT;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate s,s-dioxide;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic Acid S,S-Dioxide Sodium Salt;S-1574;Stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid s,s dioxide sodium salt;Sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide;
CAS: 30123-17-2;
MF: C21H24ClN2NaO4S ;
MW: 458.93;
EINECS: 250-059-3
Description:
Tianeptine sodium salt is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.
COA:
Product Name | Tianeptine sodium |
Batch No. | 160625 | Mfg. date | 2016-6-25 |
Test Date | 2016-6-25 | Exp. date | 2018-6-24 |
Tests | Specifications | Results |
Description | White to yellowish powder, very hygroscopic. | Off-white powder, very hygroscopic. |
Solubility | Freetly soluble In water and methanol and dichloromethane | Complies |
Identification | (1)By IR, To match with working standard | Complies |
(2)It gives reaction of sodium | Complies |
Impurities A | ≤0.1% | Not detected |
Related compounds | Any impurity ≤0.1% | <0.1% |
Total impurities ≤0.4% | 0.25% |
Residual Solvents | Acetidin≤ 0.5% | Not detected |
Dichloromethane≤ 0.06% | Not detected |
Methanol≤ 0.3% | Not detected |
Acetone ≤ 0.5% | Not detected |
Acetonitrile≤0.041% | Not detected |
Ethanol≤0.5% | 0.04% |
N, N-dimethylformamide≤0.088% | Not detected |
Water | ≤ 5.0% | 1.38% |
Assay | 99.0%-101.0%(On anhydrous basis) | 99.98% |
Conclusion | Conform to EP8.0 |
Application
Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).
Packaging and shipping
25kg
Company
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Quality Pharmaceutical Intermediate Tianeptine Sodium CAS 30123-17-2 for Nootropic