| Description |
Tianeptine sodium salt is a selective facilitator of 5-HT uptake
in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no
affinity for a wide range of receptors, including 5-HT and dopamine
(IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake.
Antidepressant, analgesic and neuroprotective following systemic
administration in vivo. |
| Related Catalog |
Signaling Pathways >>
GPCR/G Protein >>
5-HT Receptor
Signaling Pathways >>
Neuronal Signaling >>
5-HT Receptor
Research Areas >>
Neurological Disease
|
| Solvent |
In Vitro: H2O : ≥ 235 mg/mL (512.06 mM) * "≥" means soluble, but saturation unknown.
|
| Solubility |
1 mM2.1790 mL10.8949 mL21.7898 mL5 mM0.4358 mL2.1790 mL4.3580 mL10 mM0.2179 mL1.0895 mL2.1790 mL
|
| Storage |
Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month
|
| Shipping |
Room temperature in continental US; may vary elsewhere
|
| SMILES |
O=C(CCCCCCNC(C1=CC=CC=C1N2C)C3=CC=C(C=C3S2(=O)=O)Cl)[O-].[Na+]
|
| References |
[1]. Broqua
P; Baudrie V; Chaouloff F Differential effects of the novel
antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP)-elicited
corticosterone release and body weight loss. Eur Neuropsychopharmacol.
1992 Jun;2(2):115-20. [2]. Orescanin-Dusic
Z, et al. Tianeptine's effects on spontaneous and Ca2+-induced uterine
smooth muscle contraction. Acta Physiol Hung. 2012 Jun;99(2):140-7. [3]. Della
FP, Abelaira HM, Réus GZ, Ribeiro KF, Antunes AR, Scaini G, Jeremias
IC, Dos Santos LM, Jeremias GC, Streck EL, Quevedo J.Tianeptine
treatment induces antidepressive-like effects and alters BDNF and energy
metabolism in the brain of rats.Behav Brain Res. 2012 Aug
1;233(2):526-35. Epub 2012 May 31. [4]. Sohn
W, Lee OY, Kwon JG, Park KS, Lim YJ, Kim TH, Jung SW, Kim JI.Tianeptine
vs amitriptyline for the treatment of irritable bowel syndrome with
diarrhea: a multicenter, open-label, non-inferiority, randomized
controlled study.Neurogastroenterol Motil. 2012 Sep;24(9):860-e398. [5]. Orola
L, Veidis MV, Sarcevica I, Actins A, Belyakov S, Platonenko A.The
effect of pH on polymorph formation of the pharmaceutically active
compound tianeptine.Int J Pharm. 2012 Aug 1;432(1-2):50-6. Epub 2012 Apr
30.
|
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China
