| Name | Thioperamide maleate |
| Description | Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM). |
| In vitro | Thioperamide maleate (0.01, 0.1, 1, 10, 100 μM) promotes the viability of NE-4C stem cells in a concentration-dependent manner[1]. Thioperamide maleate displays similar potencies at human H4 and H3 receptors with Kis of 43 and 60 nM, respectively[2]. Thioperamide maleate inhibits [3H]-(R)α-MeHA binding rat brain and guinea-pig lung with Kis of 2.1 nM and 2.0 nM, respectively. Thioperamide maleate competitively blocks H3-autoreceptors regulating [3H]histamine release with a mean apparent Ki of 4 nM[4]. |
| In vivo | In C57BL/6J mice, Thioperamide (5-20 mg/kg; i.p.) facilitates reconsolidation of a contextually-conditioned fear memory[3]. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (134.63 mM), Sonication is recommended.
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| Keywords | Thioperamide maleate | Thioperamide Maleate | Thioperamide | MR-12842 Maleate | MR12842 Maleate | MR-12842 | MR12842 | MR 12842 Maleate | MR 12842 | Inhibitor | inhibit | HistamineReceptor | Histamine Receptor | H3 receptor |
| Inhibitors Related | Chlorphenesin | Meclizine dihydrochloride | Mirtazapine | Lidocaine | Famotidine | Loratadine | Mebhydrolin napadisylate | Sodium butanoate | Amitriptyline hydrochloride | Alginic acid | Trazodone hydrochloride | Mianserin hydrochloride |
| Related Compound Libraries | Histamine & Melatonin Receptor-Targeted Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library |
United States
