| 名称 | Tetrandrine |
| 描述 | Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels. |
| 体外活性 | METHODS: Leukemia cell lines K562, THP-1, U937, and HL60 were treated with Tetrandrine (1-3 µM) for 24-72 h, and cell numbers were measured.
RESULTS: 2 µM and 3 µM Tetrandrine significantly inhibited cell proliferation. [1]
METHODS: A panel of GFP-LC3-expressing tumor cell lines MCF-7, PLC-5, SK-Hep1, HeLa, and PC3 cells were treated with Tetrandrine (5 µM) for 16 h and GFP-LC3 spots were detected.
RESULTS: Tetrandrine significantly induced GFP-LC3 spot formation with similar potency (5 µM) in all cell lines tested.Tetrandrine induced autophagy in multiple cell lines. [2] |
| 体内活性 | METHODS: To detect anti-tumor activity in vivo, athymic nude mice bearing THP-1 xenografts were administered Tetrandrine (25-50 mg/kg, 0.5% methylcellulose) by gavage once daily for 13 days.
RESULTS: Tetrandrine treatment reduced tumor growth. [1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 0.7 mg/mL (1.12 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 50 mg/mL (80.29 mM)
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| 关键字 | Ca channels | KcsA | Potassium Channel | NSC 77037 | Calcium Channel | NSC77037 | Ca2+ channels | inhibit | Tetrandrine | Inhibitor |
| 相关产品 | Minoxidil sulfate | Nisoldipine | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | Lanthanum(III) chloride heptahydrate | Halothane | Ethyl cinnamate | 1-Octanol | Indapamide |
| 相关库 | 经典已知活性库 | 中药单体化合物库 | 膜蛋白靶向化合物库 | 生物碱类天然产物库 | 天然产物库 | 药物功能重定位化合物库 | 抗癌上市药物库 | 离子通道库 | 古代经典名方目录分子库 | 药食同源库 |
United States
