| 名称 | Tetracycline |
| 描述 | Tetracycline (Tetracyclin) is a broad-spectrum antibiotic with inhibitory activity against a wide range of Gram-positive and Gram-negative bacteria, as well as Mycoplasma, Mycoplasma, and Rickettsia. Tetracycline is commonly used in anti-infective studies. |
| 体外活性 | METHODS: Neuroblastoma cells were treated with Binimetinib (0-2 µM) for 24-120 h. Cell viability was measured by MTT assay.
RESULTS: Four cell lines, CHP-212, SK-N-BE, SK-N-AS and SJ-NB-10, were sensitive to Binimetinib, achieving <50% survival after 24-120 h of treatment, while five cell lines were resistant to the drug. [1]
METHODS: NSCLC cells A549, H157 and H522 were treated with Binimetinib (0.5-1 µM) for 48 h. Cell cycle was measured by flow cytometry.
RESULTS: Binimetinib induced G1 phase block in three sensitive NSCLC cell lines at relatively low concentration ranges, e.g. 0.5 and 1 µM. [2] |
| 体内活性 | METHODS: To detect in vivo antitumor activity, Binimetinib (5 mg/kg) and BMK120 (7.5 mg/kg) were administered by gavage to athymic (nu/nu) mice bearing A549 xenografts once daily for 21 days.
RESULTS: Binimetinib and BKM120 alone at the doses tested only weakly inhibited the growth of A549 xenografts, but the combination of Binimetinib and BKM120 significantly inhibited the growth of A549 xenografts. [2] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 15 mg/mL (33.75 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 45 mg/mL (101.25 mM), Sonication and heating are recommended.
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| 关键字 | inhibit | broad-spectrum | Inhibitor | oral | Bacterial | Tetracycline | Antibiotic |
| 相关产品 | Neomycin sulfate | Kanamycin sulfate | Sulfamethoxazole sodium | Doxycycline | Dimethyl sulfoxide |
United States
