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ChemicalBook Product Catalog Biochemical Engineering Plant extracts Terrestrosin D

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Terrestrosin D NEW

$35.00 1mg

$89.00 5mg

$135.00 10mg

Min. Order
Purity99.96%
Cas No179464-23-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Terrestrosin D
CAS No	179464-23-4
EC-No
Min. Order
Purity	99.96%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Terrestrosin D
Description	Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of terrestrosin D.
In vitro	The aim of this study was to investigate whether Terrestrosin D (TED) inhibits the progression of castration-resistant prostate cancer and consider its mechanism. METHODS AND RESULTS: Cell cycle, mitochondrial membrane potential (ΔΨm) and apoptosis were determined by flow cytometry. Caspase-3 activity and vascular endothelial growth factor secretion were detected by a caspase-3 assay and human vascular endothelial growth factor kit, respectively. A PC-3 xenograft mouse model was used to evaluate the anticancer effect of TED in vivo. In vitro, TED strongly suppressed the growth of prostate cancer cells and endothelial cells in a dose-dependent manner. TED induced cell cycle arrest and apoptosis in PC-3 cells and human umbilical vascular endothelial cells (HUVECs). TED-induced apoptosis did not involve the caspase pathway. TED also decreased ΔΨm in PC-3 cells and HUVECs. In vivo, TED significantly suppressed tumor growth in nude mice bearing PC-3 cells, without any overt toxicity. Immunohistochemical analysis showed TED induced apoptotic cell death and inhibited angiogenesis in xenograft tumor cells. CONCLUSIONS: Cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of actions for the observed antitumor and antiangiogenic activities of TED.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 30 mg/mL (28.59 mM)
Keywords	Inhibitor \| inhibit \| Terrestrosin D \| Apoptosis
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Myricetin \| Meclizine dihydrochloride \| Dextran sulfate sodium salt (MW 4500-5500) \| Sodium 4-phenylbutyrate \| L-Ascorbic acid \| Metronidazole \| Sorafenib \| Tributyrin \| Salicylic acid \| Oleic acid
Related Compound Libraries	Anti-Tumor Natural Product Library \| Apoptosis Compound Library \| Bioactive Compound Library \| Traditional Chinese Medicine Monomer Library \| Selected Plant-Sourced Compound Library \| Natural Product Library \| Natural Product Library for HTS \| Bioactive Compounds Library Max \| Ancient Chinese Classical Formulas Compound Library \| Anti-Cancer Active Compound Library

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