| Name | Tenovin-1 |
| Description | Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. |
| Cell Research | Cell viability isdetermined by trypan blue exclusion, Giemsa staining, or MTT assays.(Only for Reference) |
| In vitro | Tenovin-1 (10 μM) protected p53 from mdm 2-mediated degradation, but had little effect on p53 protein synthesis. When applied to p53-expressing tumor cells, Tenovin-1 inhibited cell growth and induced apoptosis.Tenovin-1 is a p53 activator and increased the amount of p53 protein within 2 h of treatment.Tenovin-1 did not affect p53 mRNA levels. |
| In vivo | Tenovin-1 (10 μM) protected p53 from mdm 2-mediated degradation, but had little effect on p53 protein synthesis. When applied to p53-expressing tumor cells, Tenovin-1 inhibited cell growth and induced apoptosis.Tenovin-1 is a p53 activator and increased the amount of p53 protein within 2 h of treatment.Tenovin-1 did not affect p53 mRNA levels. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 9.2 mg/mL (25 mM)
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| Keywords | Dihydroorotate Dehydrogenase | Autophagy | Sirtuin | inhibit | MDM-2/p53 | DHODH | Tenovin1 | Tenovin-1 | MDM2 | degradation | acetylation | protein-deacetylating | Inhibitor |
| Inhibitors Related | Stavudine | Xylitol | Myricetin | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Histone Modification Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Autophagy Compound Library | Glutamine Metabolism Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
United States
