| Name | Tempone |
| Description | Tempone is an aminooxyalkane that acts as a free radical scavenger and reacts with reactive oxygen species (ROS). Intravenous Tempone reduces mean arterial pressure in spontaneously hypertensive rats. |
| In vivo | Tempone (100 mg/kg i.v. bolus followed by 30 mg/kg i.v. infusion; rats) significantly improved both glomerular and tubular function (serum urea, creatinine, creatinine clearance, and fractional excretion of Na(+)) in a dose-dependent manner and significantly attenuated the reperfusion-injury associated with I/R (urinary N-acetyl-beta-D-glucosaminidase, aspartate aminotransferase, assessment of renal histology). Tempone also markedly reduced the immunohistochemical evidence of the formation of nitrotyrosine and poly(ADP-ribose), indicating a reduction of nitrosative and oxidative stress, respectively. Importantly, in contrast to its in vivo metabolite TEMPOL (which also provided protective effects against renal I/R and oxidative stress of PT cells), Tempone reduced renal dysfunction and injury without causing a significant reduction in blood pressure upon administration. These results suggest, for the first time, that Tempone can reduce the renal dysfunction and injury caused by I/R and the injury caused to PT cells by oxidative stress without producing the adverse cardiovascular effects observed when using other nitroxyl radicals.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (264.35 mM), Sonication is recommended.
PBS (pH 7.2) : 10 mg/mL (58.74 mM), Sonication is recommended.
DMF : 30 mg/mL (176.23 mM), Sonication is recommended.
Ethanol : 30 mg/mL (176.23 mM), Sonication is recommended.
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| Keywords | Tempone | ROS |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Imeglimin hydrochloride | L-Ascorbic acid | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Dimethyl itaconate | L-Ascorbic acid sodium salt | Dimethyl phthalate |
| Related Compound Libraries | Bioactive Compound Library | Antioxidant Compound Library | Anti-Cardiovascular Disease Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
