1. Product information
Use of TCMDC-124283
2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1].
| Name | 2-fluoroadenine |
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| Synonym | More Synonyms |
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TCMDC-124283 Biological Activity
| Description | 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1]. |
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| Related Catalog | Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis |
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| Target | DNA/RNA synthesis[1] |
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| In Vitro | 2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis[1]. 2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity in nonproliferating MRC-5 cells[1]. 2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses in Balb-3T3 cells incubated in serum-free medium[1]. Cell Proliferation Assay Cell Line: CEM cells[1] Concentration: 2 μM Incubation Time: 4 hours Result: Inhibited CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. Cell Cytotoxicity Assay Cell Line: MRC-5 cells[1] Concentration: 0-1000 μM Incubation Time: 4 hours Result: Exhibited cytotoxicity in nonproliferating MRC-5 cells. |
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| References | [1]. Parker WB, et al. Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochem Pharmacol. 1998;55(10):1673-1681. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Boiling Point | 676.9±58.0 °C at 760 mmHg |
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| Melting Point | >350 °C(lit.) |
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| Molecular Formula | C5H4FN5 |
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| Molecular Weight | 153.12 |
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| Flash Point | 363.2±32.3 °C |
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| Exact Mass | 153.045074 |
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| PSA | 80.48000 |
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| LogP | -0.01 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.783 |
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| Storage condition | Refrigerator |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
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