| Name | TCH-165 |
| Description | TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs. |
| In vitro | TCH-165, resulting in an increase in 20S levels.?The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs, including α-synuclein, tau, ornithine decarboxylase, and c-Fos, but not structured proteins.?Clearance of ubiquitinated protein was largely maintained by single capped proteasome complexes (19S-20S), but accumulation occurs when all 19S capped proteasome complexes are depleted[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (83.93 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (8.39 mM), Sonication is recommended.
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| Keywords | α-syn | trypsin-like | TCH-165 | TCH165 | TCH 165 | tau | Proteasome assembly | Proteasome | Inhibitor | inhibit | IDPs | degradation | chymotrypsin-like | caspase-like | assembly | 20S |
| Inhibitors Related | Tripterin | Sitagliptin | Teneligliptin hydrobromide | Sitagliptin phosphate monohydrate | 10-Undecenoic acid | Anagliptin | Aprotinin | 10-Undecenoic acid zinc salt | Vildagliptin | Sitagliptin phosphate | Alloxan monohydrate | 4'-Hydroxychalcone |
| Related Compound Libraries | Bioactive Compound Library | Ubiquitination Compound Library | HIF-1 Signaling Pathway Compound Library | Hematonosis Compound Library | Protease Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
United States
