| 名称 | Tauroursodeoxycholate |
| 描述 | Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. |
| 体外活性 | METHODS: HeLa cells overexpressing the WDR45 mutation were treated with Tauroursodeoxycholate (200 µM) for 24 h, and the expression levels of target proteins were measured by Western Blot.
RESULTS: Inhibition of ER stress with Tauroursodeoxycholate significantly reduced the phosphorylation of p38 and LAMP2A as well as the punctate formation of mCherry KFERQ in cells expressing mutant WDR45. [1]
METHODS: Undifferentiated neural stem cells NSCs were treated with Tauroursodeoxycholate (100 µM) for 24 h and cell proliferation was detected by Flow cytometry via BrdU.
RESULTS: BrdU incorporation increased significantly after incubation with Tauroursodeoxycholate, and Tauroursodeoxycholate regulated cell proliferation. Tauroursodeoxycholate regulates cell proliferation.[2] |
| 体内活性 | METHODS: To test the effect on diabetes, Tauroursodeoxycholate (300 mg/kg) was administered intraperitoneally to STZ-induced diabetic C57BL/6 mice once daily for 24 days.
RESULTS: After 15 days of treatment, STZ+Tauroursodeoxycholate mice had a 43% reduction in blood glucose compared to the STZ group. This decrease may be due to an increase in insulinemia. [3] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 5% DMSO+95% Saline : 4.5 mg/mL (9.01 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 6.25 mg/mL (12.51 mM), Sonication is recommended.
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| 关键字 | Endogenous Metabolite | reticulum | ERK | Caspase | caspase-12 | Extracellular signal regulated kinases | molecules | UR906 | inhibit | Apoptosis | UR-906 | endoplasmic | stress | Tauroursodeoxycholate | caspase-3 | Inhibitor |
| 相关产品 | Sucrose | Tributyrin | Glycerol | Thymidine |
| 相关库 | 激酶抑制剂库 | 药物功能重定位化合物库 | 天然产物库 | 中药抗炎分子库 | FDA 上市药物库 | 人内源代谢化合物库 | 肠道微生物代谢化合物库 |
United States
