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ChemicalBook Product Catalog Taurochenodeoxycholic acid sodium

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Taurochenodeoxycholic acid sodium NEW

$ 46.00 /100mg

Min. Order
Purity98.23%
Cas No6009-98-9
Supply Ability10g
Update time2025-11-02

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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Chemical Properties

Product Name	Taurochenodeoxycholic acid sodium
CAS No	6009-98-9
EC-No
Min. Order
Purity	98.23%
Supply Ability	10g
Release date	2025/11/02

Product Introduction

Bioactivity

Name	Taurochenodeoxycholic acid sodium
Description	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties. It can increase glucose-induced insulin secretion and stimulate the electrical activity of α2-cells and enhance cytosolic Ca(2+) concentration ([Ca(2+)](c)).
In vitro	Experiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and β-cell ATP-dependent K(+) (K(ATP)) channel gene SUR1 (ABCC8) KO mice, respectively. Sodium taurochenodeoxycholate (TCDC) increased glucose-induced insulin secretion. This effect was mimicked by the FXR agonist GW4064 and suppressed by the FXR antagonist guggulsterone. TCDC and GW4064 stimulated the electrical activity of β-cells and enhanced cytosolic Ca(2+) concentration ([Ca(2+)](c)). These effects were blunted by guggulsterone. Sodium ursodeoxycholate, which has a much lower affinity to FXR than TCDC, had no effect on [Ca(2+)](c) and insulin secretion. FXR activation by TCDC is suggested to inhibit K(ATP) current. The decline in K(ATP) channel activity by TCDC was only observed in β-cells with intact metabolism and was reversed by guggulsterone. TCDC did not alter insulin secretion in islets of SUR1-KO or FXR-KO mice. TCDC did not change islet cell apoptosis.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 25 mg/mL (47.92 mM), Sonication is recommended.
Keywords	TNF-α \| TIMP-2 \| Taurochenodeoxycholic acid sodium \| Taurochenodeoxycholic acid \| regulation \| Potassium Channel \| PKC \| NR8383 \| mRNA \| JNK \| Inhibitor \| inhibit \| immune \| EndogenousMetabolite \| Endogenous Metabolite \| caspase-8 \| caspase-3 \| Calcium Channel \| bile \| ATPase \| apoptosis \| Apoptosis \| anti-inflammatory \| acid \| 12-Deoxycholyltaurine
Inhibitors Related	Sucrose \| Cysteamine hydrochloride \| Urea \| Levulinic acid \| D(+)-Raffinose pentahydrate \| Daidzein \| Tributyrin \| Ferulic Acid \| Glycerol \| Thymidine \| Alginic acid \| 3-Indoleacetic acid
Related Compound Libraries	Anti-Tumor Natural Product Library \| Apoptosis Compound Library \| Bioactive Compound Library \| NO PAINS Compound Library \| Immunology/Inflammation Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Bioactive Lipid Compound Library \| Bile Acids Library

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