| Name | Tandospirone |
| Description | Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders. |
| In vitro | Tandospirone has negligible effects at 5-HT1B receptors, 5-HT uptake sites, β-adrenergic receptors, muscarinic cholinergic receptors, and benzodiazepine receptors. [1]3H-Tandospirone rapidly binds to rat brain hippocampal membranes and achieves binding in a high-affinity, reversible, and saturating fashion (Kd: 9.4 nM, Bmax: 213 fmol/mg protein). [2] |
| In vivo | Chronic administration of Tandospirone (0.2 and 1.0 mg/kg/day, but not 2.0 mg/kg/day) was effective in alleviating elevated levels of eLAC in the anterior cingulate cortex (mPFC) due to foot shock stress. [3] After acute administration of Tandospirone (0, 0.1 and 1 mg/kg, intraperitoneally) to rats, a significant reduction in the number of premature responses in a dose-dependent manner was observed, an index used to assess impulsive behavior. [4] |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble)
DMSO : 15 mg/mL (39.11 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.22 mM), Sonication is recommended.
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| Keywords | Tandospirone | SM 3997 | 5HTReceptor | 5-HT1A | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | pCPA methyl ester hydrochloride | 1,8-Cineole | Venlafaxine hydrochloride | Tryptamine hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Drug-induced Liver Injury (DILI) Compound Library | Toxic Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | NMPA-Approved Drug Library |
United States
