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ChemicalBook Product Catalog Talazoparib tosylate

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Talazoparib tosylate NEW

$ 35.00 /2mg

Min. Order
Purity99.79%
Cas No1373431-65-2
Supply Ability10g
Update time2025-09-29

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

United States

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Chemical Properties

Product Name	Talazoparib tosylate
CAS No	1373431-65-2
EC-No
Min. Order
Purity	99.79%
Supply Ability	10g
Release date	2025/09/29

Product Introduction

Bioactivity

Name	Talazoparib tosylate
Description	Talazoparib tosylate (BMN 673ts) is an orally active and highly potent PARP1/2 inhibitor with antitumor activity for the study of specific breast cancers.
In vitro	Talazoparib tosylate had similar inhibitory effects on PARP1 and PARP2 (Ki values of 1.20 nM and 0.85 nM, respectively). Talazoparib tosylate induced the formation of an intranuclear γ-H2AX focus at concentrations as low as 100 pM. Talazoparib tosylate had no effect on PARG activity at concentrations up to 1 μM. The dissociation constant for binding of Talazoparib tosylate to PARP1 was 0.29 nM. Talazoparib tosylate selectively targets tumor cells with defects in the BRCA1, BRCA2 or PTEN genes with 20- to 200-fold greater potency than existing PARP1/2 inhibitors. Talazoparib tosylate specifically targets tumor cells with defects in homologous recombination genes, and tumor models with defects in BRCA1 or BRCA2 defective tumor models are extremely sensitive to Talazoparib tosylate. [1]
In vivo	Talazoparib tosylate has high oral bioavailability, with absolute bioavailability exceeding 40% when administered orally in rats using carboxymethylcellulose as the vehicle. Talazoparib tosylate has significant antitumor effects when administered orally; Talazoparib tosylate exhibits high potency sensitivity in transplanted tumors with impaired DNA repair due to BRCA mutations or PTEN defects when administered at well-tolerated doses in mice. [1]
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O : < 0.1 mg/mL (insoluble) DMSO : 100 mg/mL (180.98 mM), Sonication is recommended.
Keywords	PARP2 \| PARP1
Inhibitors Related	4'-Methoxychalcone \| Niraparib tosylate monohyrate \| VPC-70063 \| 3-Aminobenzamide \| XAV-939 \| Niraparib \| 3-Methoxybenzamide \| NU1025 \| Olaparib \| Benzamide \| Picolinamide \| OUL35
Related Compound Libraries	Bioactive Compound Library \| Anti-Ovarian Cancer Compound Library \| FDA-Approved Drug Library \| Bioactive Compounds Library Max

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