Tacrolimus Monohydrate CAS 109581-93-3 With Safe Delivery
Product Name: Tacrolimus Monohydrate
Synonyms: FK-506;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;TACROLIMUS HYDRATE/TSUKUBAENOLIDE HYDRATE;(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone;Tacrolimus (150 mg);(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-Methoxycyclohexyl]-1-Methylethenyl]-14,16-diMethoxy-4,10,12,18-tetraMethyl-8-(2-propen-1-yl)-;Tacrolimus monohydrate;FK-506 monohydrate, >=98%
CAS: 109581-93-3
MF: C44H71NO13
MW: 822.05
EINECS:
Product Categories: Signalling
Mol File: 109581-93-3.mol
Tacrolimus Monohydrate CAS 109581-93-3 is a pharmaceutical compound that is a monohydrate form of Tacrolimus. Tacrolimus is a macrolide immunosuppressant drug that is used to prevent rejection in organ transplant patients. Tacrolimus Monohydrate is a white or off-white crystalline powder that is soluble in water, ethanol, and meth anol.
The monohydrate form of Tacrolimus is used in the production of Tacrolimus capsules and other dosage forms. It is used to improve the solubility and stability of Tacrolimus in the manufacturing process, which can help to ensure the quality and consistency of the drug.
Tacrolimus Monohydrate works by inhibiting the activity of T-cells, which are involved in the immune response. By suppressing the immune system, Tacrolimus Monohydrate can help prevent the body from rejecting a transplanted organ.
Tacrolimus Monohydrate CAS 109581-93-3 of Chemical Properties
Melting point 127-129°
alpha D23 -84.4° (c = 1.02 in chloro form)
storage temp. -20°C
solubility DMSO: soluble20mg/mL
form powder
color White to Almost white
Merck 14,9025
InChIKey NWJQLQGQZSIBAF-MLAUYUEBSA-N
Function and Application of Tacrolimus Monohydrate CAS 109581-93-3
Tacrolimus Monohydrate CAS 109581-93-3 is a pharmaceutical compound used in the production of Tacrolimus, a macrolide immunosuppressant drug. Here are some functions and applications of Tacrolimus Monohydrate:
1. Organ transplant: Tacrolimus Monohydrate is used to prevent organ rejection in patients who have undergone organ transplantation. It works by suppressing the immune system, which helps to prevent the body from rejecting the transplanted organ.
2. Skin disorders: Tacrolimus Monohydrate is also used topically to treat skin disorders such as eczema and psoriasis. It helps to reduce inflammation and itching associated with these conditions.
3. Autoimmune diseases: Tacrolimus Monohydrate is used to treat autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. It helps to suppress the immune system, which is overactive in these conditions and attacking the body's own tissues.
4. Ophthalmology: Tacrolimus Monohydrate is also used in ophthalmology to treat certain eye disorders such as uveitis and ocular surface diseases.
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Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria, including infections of the respiratory tract, skin and soft tissue infections, and peritonitis.In patients with hypersensitivity to penicillins,
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Function of Clindamycin Hydrochloride
clindamycin may be used to treat infections caused by susceptible aerobic bacteria as well. It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus. Topical application of clindamycin phosphate can be used to treat mild to moderate acne.
Application of Clindamycin Hydrochloride
It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus (MRSA) infections. The most severe common adverse effect of clindamycin is Clostridium difficile-associated diarrhea (the most frequent cause of pseudomembranous colitis). Although this side effect occurs with almost all antibiotics, including beta-lactam antibiotics, it is classically linked to clindamycin use.
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