Basic information Safety Related Supplier

ChemicalBook Product Catalog T807

1/1

T807 NEW

$39.00 2mg

$64.00 5mg

$109.00 10mg

Min. Order
Purity99.72%
Cas No1415379-56-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

show more

Chemical Properties

Product Name	T807
CAS No	1415379-56-4
EC-No
Min. Order
Purity	99.72%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	T807
Description	T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).
In vitro	In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections with Kd of 14.6 nM. Comparison of autoradiography and double immunohistochemical staining of adjacent sections of PHF-tau and Ab showed that [18F] T807 binding is colocalized with immunoreactive PHF-tau pathology, but does not highlight Ab plaques[1]. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified[2].
In vivo	[18F]T807 can cross the blood-brain barrier and ished out quickly in mice models. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 1 mg/ml, Sonication is recommended.
Keywords	T-807 \| AV1451 \| T 807 \| Inhibitor \| inhibit \| AV 1451 \| T807
Inhibitors Related	Flubendazole \| Mebendazole \| N-Phenylbenzylamine \| T-900607 \| 4-Isopropoxybenzoic acid \| Oxfendazole \| Thiabendazole \| Methylene Blue \| Methylene Blue trihydrate \| Paclitaxel \| Benproperine phosphate \| 4'-Demethylepipodophyllotoxin
Related Compound Libraries	Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| Anti-Alzheimer's Disease Compound Library \| Drug Repurposing Compound Library \| Microtubule-Targeted Compound Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Cytoskeletal Signaling Pathway Compound Library

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book