Name | suvn-911 |
Description | suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity. |
In vitro | SUVN-911 demonstrates high selectivity towards α4β2 over α3β4 nACh receptors, standing out against a broad spectrum of over 70 targets, including GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors, and prostaglandins. This specificity underscores its promising potential in targeted pharmacological applications. |
In vivo | In male Wistar rats, suvn-911 (1.0-10.0 mg/kg; p.o.) showed significant antidepressant-like activity with no signs of tachyphylaxis. suvn-911 (3 mg/kg; p.o.) showed high oral exposures, longer half-lives(T1/2 = 3.34 hr), and adequate brain penetration in Wistar rats. suvn-911 showed metabolic stability and no cardiovascular and gastrointestinal side effects[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 50.00 mg/mL (191.46 mM), Sonication is recommended.
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Keywords | nicotinic | antidepressant | nAChR | acetylcholine | neuronal | Inhibitor | SUVN-911 | suvn911 | suvn 911 | depression | inhibit | Nicotinic acetylcholine receptors | suvn-911 |
Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Pilocarpine nitrate | CLOZAPINE N-OXIDE | Ribavirin | Adenine | Amitriptyline hydrochloride | Choline chloride | Propoxur |
Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Ion Channel Targeted Library |